Sepsis Fact Sheet

Here are some important facts about the state of sepsis in the United States and globally.

Sepsis in the United States

  • More than 1.5 million people in the United States develop sepsis each year.[i]
  • At least 270,000 people in the United States die each year from sepsis.[ii]
  • Sepsis is the leading cause of death in U.S. hospitals.[iii] As many of half of all patients who die in U.S. hospitals have sepsis.[iv]
  • Sepsis is increasing at a rate of 10.3% each year in the United States.[v]
  • One in five severe sepsis patients are readmitted to hospital within 30 days. Among those readmitted within 30 days, 66.9% had an infection and 40.3% had severe sepsis on readmission.[vi]
  • Sepsis begins outside the hospital for the vast majority (nearly 80%) of sepsis patients.[vii]
  • Sepsis is the most expensive condition treated un U.S. hospitals, costing nearly $24 billion annually. Sepsis is also the most expensive condition billed to Medicare.[viii]
  • The cost of sepsis is increasing annually by a rate of 11.9%.[ix]

Sepsis Around the World

  • Sepsis affects, at minimum, an estimated 30 million people around the world each year and results in at least 6 million deaths.[x]
  • In the developing world, sepsis accounts for 60-80% of lost lives per year, affecting more than 6 million newborns and children annually.[xi]

Sepsis and Children

  • Sepsis is the leading cause of death for infants and children worldwide.[xii]
  • 40,000 children in the United States are hospitalized each year with sepsis.[xiii]
  • Approximately 5,000 children in the United States die each year from sepsis.[xiv]
  • Every hour delay in treating a child with sepsis increases mortality by 8%.[xv]
  • The economic cost of treating pediatric sepsis is estimated to be $4.8 billion annually.[xvi]
  • 38% of children who survive sepsis sustain lifelong disabilities.[xvii]