Sepsis Facts

Here are some important facts about the state of sepsis in the United States and globally.

Sepsis in the United States

  • More than 1.7 million people in the United States develop sepsis each year. (1)
  • At least 350,000 people in the United States die each year from sepsis. (2)
  • Sepsis is the leading cause of death in U.S. hospitals.(3) As many of half of all patients who die in U.S. hospitals have sepsis. (4)
  • Sepsis is increasing at a rate of 10.3% each year in the United States. (5)
  • Sepsis begins outside the hospital for the vast majority (nearly 80%) of sepsis patients. (6)
  • Sepsis is the most expensive condition treated un U.S. hospitals, costing $62 billion annually. Sepsis is also the most expensive condition billed to Medicare. (7)
  • 75,000 children in the U.S. are hospitalized each year with severe sepsis (8) resulting in 7,000 deaths. (9)
  • Every hour delay in treating a child with sepsis increases mortality by 8%. (10)
  • Sepsis kills almost twice as many Black Americans as White Americans. (11)
  • Sepsis is the second leading cause of maternal death in the U.S. (12)
  • One in five severe sepsis patients are readmitted to hospital within 30 days. Among those readmitted within 30 days, 40.3% had severe sepsis on readmission.(13)
  • The cost of sepsis is increasing annually by a rate of 11.9%. (14)

Sepsis Around the World

  • 49 million people around the world develop sepsis each year. (1)
  • Sepsis results in 11 million deaths each year. 1 in 5 of all deaths are caused by sepsis. (2)
  • Sepsis accounts for 60-80% of lives lost in childhood. (3)
  • Sepsis is the leading cause of death for infants and children worldwide. (4)
  • 20 million children under the age of 5 develop sepsis each year; 2.9 million die as a result. (5)

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Sepsis in the Unites States

(1) https://www.cdc.gov/patientsafety/features/get-ahead-of-sepsis.html

(2) https://www.cdc.gov/patientsafety/features/get-ahead-of-sepsis.html

(3) https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)32989-7/fulltext

(4) https://jamanetwork.com/journals/jama/fullarticle/1873131

(5) https://www.ncbi.nlm.nih.gov/pubmed/28903154

(6) https://jamanetwork.com/journals/jama/fullarticle/2654187

(7) https://journals.lww.com/ccmjournal/Fulltext/2020/03000/Sepsis_Among_Medicare_Beneficiaries__3__The.4.aspx

(8) https://pubmed.ncbi.nlm.nih.gov/23897242/

​​(9) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581233/

(10) https://www.childrenshospitals.org/Quality-and-Performance/Quality-Improvement/Sepsis/Resources/Sepsis-Fact-Sheet

(11) https://pubmed.ncbi.nlm.nih.gov/30568980/

(12) https://www.cdc.gov/reproductivehealth/maternal-mortality/pregnancy-mortality-surveillance-system.htm

(13) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537666/

(14) https://www.ncbi.nlm.nih.gov/pubmed/24199255

Sepsis Globally

(1) https://www.thelancet.com/article/S0140-6736(19)32989-7/fulltext

(2) https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)32989-7/fulltext

(3) https://pubmed.ncbi.nlm.nih.gov/21897156/

(4) https://pubmed.ncbi.nlm.nih.gov/21897156/

(5) https://www.thelancet.com/article/S0140-6736(19)32989-7/fulltext